The Bighorns are a popular destination for hiking, backpacking, fly fishing, horse back riding and increasingly ATV riding and snowmobiling. Trails wind through most of the national forest. The Cloud Peak Wilderness has a network of hiking trails to remote areas and alpine lakes.

Higher trails are often covered with snow except from July through August. After Labor Day, there is a good chance of high country snow storms at any time.

The Bighorns are home to one of the elite ultramarathons in the nation. The Bighorn Trail Run. This is held every June.

The Sioux, Crow, and Cheyenne Indians have long considered the Bighorns sacred mountains.